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University of Pennsylvania researchers analyzed over 400,000 Reddit posts from nearly 70,000 users across five years and found that semaglutide and tirzepatide users are reporting menstrual irregularities and temperature complaints like chills
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Nearly half the sample reported at least one side effect, flagging menstrual irregularities, chills, and hot flashes that aren't reflected in current drug labels. Fatigue ranked as the second most common complaint
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